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Hcy self-oxidation generates ROS, disrupts redox homeostasis, and induces neuronal apoptosis via upregulation of Bax protein expression and activation of the caspase-3 pathway ( MMA further contributes to oxidative stress by impairing the mitochondrial respiratory chain complexes and energy metabolism

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Thomson A, Smart K, Somerville MS, Lauder SN, Appanna G, Horwood J, et al

The shape of the nanoparticles also affects their biodistribution, ability to be transported across endothelial cells, and the rate at which they are cleared[69]

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